
Fall Asleep Faster, Sleep Deeper, Wake Refreshed
Sleep is a blend of sustained-release melatonin, fully chelated magnesium bisglycinate, and glycine to help you fall asleep faster, sleep through the night, and wake up refreshed. Each ingredient does a different job, and each is backed by human trials. Here’s how they work:
Version 2 (2026): melatonin moved from 0.3 mg immediate-release to 0.8 mg sustained-release (Melotime®), the magnesium is now fully chelated bisglycinate, and glycine is 2,400 mg. The full list of changes is in the FAQ below.
Low-Dose, Sustained-Release Melatonin (0.8 mg)
A Gentle Signal, Released Slowly
Melatonin is the body’s natural “sleep hormone.” Meta-analyses of clinical trials show that melatonin can help people fall asleep faster [1] and improve overall sleep quality [2].
Most supplements get the dose wrong. You will often see 3 mg or even 5 mg capsules on the shelf. These flood your receptors with far more hormone than your body ever makes in a night. Sleep bases the dose on human physiology instead.
The Science of the Low Dose
Each night, your body produces somewhere between 10 and 80 mcg of melatonin [15], and direct measurements put most adults at 20–35 mcg [3, 4]. That small amount is enough to start your natural sleep process. But only about 15% of oral melatonin reaches your bloodstream [5]. Your liver breaks down the rest.
Sleep contains 0.8 mg (800 mcg) of melatonin. After absorption, roughly 120 mcg reaches your bloodstream, spread across the evening and the night rather than arriving all at once. That is a few times what your body makes on its own, and a small fraction of what a 3 mg capsule delivers.
Why sustained release?
Ordinary melatonin peaks within about an hour and its blood level falls within a few hours. That helps you fall asleep, and it leaves little melatonin for later in the night. Sleep uses Melotime®, a sustained-release form. In a head-to-head pharmacokinetic study, the sustained-release capsule produced half the peak level of an immediate-release capsule and its half-life was about 5 hours, against 1 hour for immediate-release; levels after hour 4 were higher with sustained release, though in a study of 16 people that difference was not statistically significant [14]. The dose is released gradually: a lower peak, and a lower level kept going later into the night.
Why 3 hours before bed?
Melatonin works best when it is taken before your own evening melatonin starts to rise [7]. Taking Sleep about 3 hours before you want to fall asleep moves the sleep-wake cycle earlier, and the sustained release then keeps a lower level going later into the night.
Why not take more?
In an MIT study, researchers compared 0.1 mg, 0.3 mg, and 3.0 mg in adults over 50 with sleep difficulties [6]. The 0.3 mg dose restored sleep efficiency and raised melatonin to normal nighttime levels. The 3.0 mg dose also improved sleep, but it lowered body temperature and kept melatonin elevated well into the daylight hours.
A separate study in healthy young adults found that 0.3 mg of melatonin shortened the time to fall asleep without any "hangover effects" the next morning [7]. Higher doses have been linked with morning grogginess and receptor desensitization, meaning you may need more and more to get the same effect [8].
Sleep sits in between: a low dose, released slowly, and still about a quarter of the smallest common 3 mg capsule.
Magnesium Bisglycinate (126 mg elemental, fully chelated)
Highly Absorbable Magnesium for Sleep
Magnesium is an essential mineral that supports relaxation and healthy sleep. Sleep includes 126 mg of elemental magnesium as fully chelated bisglycinate: every magnesium is bound to two glycine molecules. That makes it easy to absorb and easy on the stomach (it avoids the laxative effect magnesium oxide and citrate can cause), and the glycine it carries counts toward the glycine dose below.
In an 8-week placebo-controlled trial in older adults with poor sleep, those who took 500 mg of magnesium nightly had significantly longer sleep time, higher sleep efficiency, and shorter time to fall asleep compared to those taking a placebo [9]. A 2021 systematic review and meta-analysis also found that magnesium supplementation reduced the time it takes to fall asleep by about 17 minutes in older adults with poor sleep [10].
Glycine (2,400 mg)
The Sleep-Supporting Amino Acid
Glycine is a naturally occurring amino acid that has been studied in several human trials for its impact on sleep. It has calming neuromodulator effects and helps lower core body temperature at bedtime, which together promote better sleep architecture.
Three randomized controlled trials have demonstrated that taking 3 grams of glycine before bed can improve sleep quality, reduce time to fall asleep, and reduce fatigue the next day, all without sedative side effects [11][12][13]. Sleep includes 2,400 mg of glycine per serving, counting the glycine carried by the magnesium chelate, to help you fall asleep more easily, sleep deeper, and wake up with more energy and a clearer head.
Clean, Natural, and Blue
- No artificial colors or dyes – We use natural blue spirulina for a calming bluish hue, reminiscent of the night sky.
- No titanium dioxide – A synthetic colorant often used in supplements, but not here.
- Plant-based – Made from plant-based materials with no genetically modified ingredients.
- No unnecessary fillers – Every ingredient has a purpose. No fluff.
- Non-habit-forming – Gentle enough for nightly use without causing dependency.
- Third-party tested – Certified by Labdoor, with independent analysis by Eurofins. Label accuracy, purity, and microbiology all passed. See the Labdoor report.
Quality Assurance
We’ve partnered with a USA supplement manufacturer called ‘Makers Nutrition’ to produce Sleep by Dr Brad. Their facilities are GMP audited and FDA registered, so you can be assured that Sleep by Dr Brad is meticulously produced and thoroughly tested for quality.
Below are the stamps of approval that Makers Nutrition qualify for:
Why Most Sleep Supplements Get It Wrong
More isn't better when it comes to sleep ingredients. Most supplements use several times too much melatonin, release it all at once, and pick the cheapest form of magnesium. Sleep is formulated around what the evidence supports.
| Most Sleep Supplements | Sleep | |
|---|---|---|
| Melatonin dose | 3–10 mg, all at once | 0.8 mg, sustained release |
| Magnesium form | Oxide | Bisglycinate, fully chelated |
| Glycine | Not included | 2,400 mg |
| Unnecessary additives | Common | None |
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Frequently Asked Questions
Is Sleep vegan/vegetarian?
Yes, the Sleep capsules are vegan-friendly. The capsule shell is plant-based (no gelatin), and none of the ingredients are animal-derived.
Why take this supplement 3 hours before wanting to fall asleep?
Melatonin is a chronobiotic agent, meaning it helps set the body’s sleep-wake cycle. It works best when it is taken before your own evening melatonin starts to rise. Taking Sleep about 3 hours before you want to fall asleep moves the sleep-wake cycle earlier, so you fall asleep sooner. The sustained-release melatonin then keeps a lower level going later into the night.
What is Spirulina?
Spirulina is a natural blue-green algae (cyanobacteria). It also contains a vivid blue pigment called phycocyanin, and its extract is used as a natural coloring agent in foods and supplements. In this product, the blue color of the capsules comes from spirulina instead of artificial dyes.
Why is there a Prop65 warning?
Given that this is the first manufacturing batch, we were required to show California’s Proposition 65 warning.
Now that we have completed our first batch, and demonstrated with our Certificate of Analysis that this is a high quality product, for future batches we can remove the Prop65 warning.
Why is the melatonin dose only 0.8 mg (much lower than many other sleep aids)?
Most over-the-counter melatonin supplements contain 3–10 mg, far above what the body makes in a night (estimates range from 10 to 80 mcg [15], with most adults at 20–35 mcg on direct measurement [3, 4]). High doses can linger in the bloodstream into the next morning, which can cause grogginess or receptor desensitization over time [6, 8]. Sleep uses 0.8 mg in a sustained-release form. Only about 15% of oral melatonin is absorbed [5], so roughly 120 mcg reaches your bloodstream, released across the evening and the night rather than in one spike. In trials of 0.3 mg, a low dose improved sleep efficiency without the side effects seen at 3 mg [6, 7].
What changed in Sleep version 2?
Version 2 (batch dated February 2026, on sale from August 2026) makes three changes to the formula. Price, serving size (4 capsules) and bottle size (30 servings) are unchanged.
1. Melatonin: 0.3 mg immediate-release became 0.8 mg sustained-release (Melotime®). The version 1 dose helped people fall asleep, but immediate-release melatonin peaks within about an hour and its blood level falls within a few hours. Version 2 releases the melatonin gradually, so a lower level is kept going later into the night. The dose is higher because only about 15% of oral melatonin is absorbed [5] and that absorbed amount is now spread across roughly 8 hours instead of arriving at once. After absorption it works out to around 120 mcg, still far below a standard 3 mg capsule.
2. Magnesium is now fully chelated bisglycinate. The magnesium glycinate in version 1 was not fully chelated. In version 2 every magnesium is bound to two glycine molecules, which is the form the absorption and tolerability evidence is based on. Elemental magnesium stays at 126 mg.
3. Glycine: 2,500 mg became 2,400 mg. The label now counts the glycine carried by the magnesium chelate, and 2,400 mg is the most that fits in a 4-capsule serving. The glycine trials used 3 g [11, 12, 13], so version 2 stays close to that dose without moving to 5 capsules.
Because the melatonin now releases slowly, the suggested timing moved from 2 hours to 3 hours before you want to fall asleep. Version 2 is also third-party tested: certified by Labdoor with independent analysis by Eurofins. See the Labdoor report.
Is it safe to take this supplement every night long-term?
Yes, this supplement is designed for regular use and includes ingredients that are considered safe for long-term use in healthy adults.
Melatonin has been studied in clinical trials without evidence of withdrawal or tolerance at low doses [1, 2].
Magnesium and glycine are essential nutrients or amino acids with excellent safety profiles when used within typical supplemental ranges [9, 10] and [11, 12, 13].
As always, speak with your healthcare provider if you have underlying health conditions or are taking medications that affect sleep or neurotransmission.
Will I feel groggy the next morning after taking it?
No. High-dose melatonin (3–10 mg) can leave you drowsy because levels stay elevated into the daylight hours [6]. Sleep uses 0.8 mg in a sustained-release form, so the level stays low throughout and should have faded by morning. Low-dose melatonin was not linked with next-morning “hangover” effects in trials [6, 7], and glycine reduced next-day fatigue in a randomized trial of partially sleep-restricted adults [12]. The formula is designed to support restful sleep and a clear morning.
Questions/Comments?
If you would like any further information about Sleep, please contact us using the form below
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References
- Ferracioli-Oda, E., Qawasmi, A., & Bloch, M. H. (2013). Meta-analysis: Melatonin for the treatment of primary sleep disorders. PLoS One, 8(5), e63773. https://doi.org/10.1371/journal.pone.0063773
- Gholami, F., et al. (2022). Effect of melatonin supplementation on sleep quality: A systematic review and meta-analysis. Journal of Neurology, 269(1), 205–216. https://doi.org/10.1007/s00415-020-10381-w
- Fourtillan, J. B., et al. (2001). Melatonin secretion occurs at a constant rate in both young and older men and women. American Journal of Physiology-Endocrinology and Metabolism, 280(1), E11–E22. https://doi.org/10.1152/ajpendo.2001.280.1.E11
- Mahle, C. D., et al. (2004). Melatonin secretion in older adults with insomnia. The American Journal of Medicine, 116(2), 91–95. https://doi.org/10.1016/j.amjmed.2003.08.026
- DeMuro, R. L., et al. (2000). The absolute bioavailability of oral melatonin. Journal of Clinical Pharmacology, 40(7), 781–784. https://doi.org/10.1177/009127000004000712
- Zhdanova, I. V., et al. (2001). Melatonin treatment for age-related insomnia. Journal of Clinical Endocrinology & Metabolism, 86(10), 4727–4730. https://doi.org/10.1210/jcem.86.10.7901
- Zhdanova, I. V., et al. (1996). Effects of low oral doses of melatonin, given 2-4 hours before habitual bedtime, on sleep in normal young humans. Sleep, 19(5), 423-431. https://doi.org/10.1093/sleep/19.5.423
- Wurtman, R. J. (2005). Low melatonin doses work best for insomnia. MIT News. https://news.mit.edu/2005/melatonin
- Abbasi, B., et al. (2012). The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. Journal of Research in Medical Sciences, 17(12), 1161–1169. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703169/
- Mah, J., & Pitre, T. (2021). Oral magnesium supplementation for insomnia in older adults: A systematic review & meta-analysis. BMC Complement Med Ther, 21, 125. https://doi.org/10.1186/s12906-021-03297-z
- Inagawa, K., et al. (2006). Subjective effects of glycine ingestion before bedtime on sleep quality. Sleep and Biological Rhythms, 4(1), 75–77. https://doi.org/10.1111/j.1479-8425.2006.00193.x
- Bannai, M., et al. (2012). The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. Frontiers in Neurology, 3, 61. https://doi.org/10.3389/fneur.2012.00061
- Yamadera, W., et al. (2007). Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes. Sleep and Biological Rhythms, 5(2), 126–131. https://doi.org/10.1111/j.1479-8425.2007.00262.x
- Thanawala, S., Abiraamasundari, R., & Shah, R. (2024). Comparative pharmacokinetics of sustained-release versus immediate-release melatonin capsules in fasting healthy adults: A randomized, open-label, cross-over study. Pharmaceutics, 16(10), 1248. https://doi.org/10.3390/pharmaceutics16101248
- Kor, Y., et al. (2014). Preliminary study: Evaluation of melatonin secretion in children and adolescents with type 1 diabetes mellitus. Indian Journal of Endocrinology and Metabolism, 18(4), 565–568. https://doi.org/10.4103/2230-8210.137521