Choline in Pregnancy: What the New IQ Trial Found
NR and NMN Evidence: What the NOPARK Trial Found
NR (nicotinamide riboside) and NMN are sold as ways to raise NAD, a molecule central to metabolism. This article walks through the evidence behind them, from the first mouse studies to NOPARK, a ye...
Sulforaphane and Astaxanthin: What the Human Trials Show
Sulforaphane, from broccoli sprouts, and astaxanthin, the red pigment in salmon, are both sold as ways to switch on NRF2, a pathway that controls the body’s own detox and antioxidant enzymes. This ...
Lp(a)HORIZON Trial Failed: What It Means for Lp(a)
Lipoprotein(a), or Lp(a), is a cholesterol-carrying particle set mostly by your genes, and about one in five people have high levels. In September 2026, Lp(a)HORIZON, a large outcome trial of a dru...
Collagen for Skin: What the 2026 Evidence Shows
Collagen supplements for skin have swung from promising to written off and back again. This article walks through the 2021, 2023 and 2025 meta-analyses, the 2026 paper that called them unreliable, ...
Waist-to-Height Ratio vs ApoB: Which Heart Number Matters?
Coronary calcium scans, fasting insulin, HbA1c, blood pressure, LDL cholesterol, ApoB and BMI all compete for the title of the one number to watch for heart attack risk. This article compares what ...
Is Obesity Ending? What GLP-1 Drug Trials Show
In the US, adult obesity climbed from about 13% in the early 1960s to more than 40% by 2017–18 [1]. Here is why it rose, and what the new weight-loss medicines, which mimic a gut hormone called GLP...
LDL, ApoB and Heart Attack Risk: What the Evidence Shows
Age-adjusted deaths from heart disease in the United States fell 72.6% between 1950 and 2019, from 588.8 to 161.5 per 100,000 [1]. That decline did not come from one breakthrough. It came from iden...
Daraxonrasib, RAS Inhibitors and Personalized Cancer Vaccines: What Changed in 2026
On August 26, 2026, the US Food and Drug Administration approved daraxonrasib for adults with metastatic pancreatic cancer that had already been treated once [1]. On its own, one approval is a head...
Vitamin K2 and Artery Calcification: What Two 2026 Trials Found
Two randomized trials published in 2026 found that vitamin K2 slowed the build-up of calcium in coronary arteries. A Dutch trial in people with moderate calcium scores reported a 22-unit smaller ri...
Why Iodine Deficiency Is Coming Back (and How to Get Enough)
For most of the twentieth century, Americans got more iodine than they needed without ever thinking about it. That is no longer true. National survey data show median iodine levels in US adults fel...
Every Cancer Vaccine Failed, Until Now
On August 19, 2026, Merck and Moderna announced that the first Phase 3 trial of an individualized cancer vaccine had met its endpoints in melanoma — and Moderna's share price rose 177% in one tradi...
Do GLP-1 Drugs Cause Blindness? What The Evidence Shows
A claim made on a major podcast in August 2026 — that sudden blindness has doubled because of GLP-1 medicines — travelled a long way in a short time [1]. It is worth separating what the underlying ...
Do Multivitamins Actually Work? What The Trials Show
"Expensive urine" is the most durable criticism ever levelled at multivitamins. It dates from a 2007 television segment, it is repeated constantly, and for years it was a fair reading of the scienc...
How To Increase Bone Density: What Actually Works
Bone density is one of the few areas of health where the popular advice and the trial evidence point in genuinely different directions. Most people reach for a calcium supplement. The research keep...
Does Lowering IL-6 Inflammation Reduce Heart Disease? What The Trials Show
Chronic inflammation has been named as a driver of heart disease for the better part of three decades. That claim now has its cleanest test — and the answer is not the one the field expected. In J...
How to Reduce Visceral Fat: An Evidence-Based Guide
Visceral fat is the fat stored deep inside the abdomen, wrapped around organs such as the liver and intestines. It is far more metabolically active than the soft fat under the skin, and it carries ...
Does Ezetimibe Work? What the Evidence Shows
In August 1990, a chemist named Duane Burnett walked into John Clader's office in New Jersey to discuss the results of their failed experiment. Together, they had spent months building molecules to...
BPC-157: Does It Work, and Did It Just Get FDA Approval?
BPC-157 is one of the most talked-about peptides on the internet. Athletes inject it for tendon and joint injuries, podcast guests credit it with fixing pain that nothing else could touch, and in J...
Jeremy Clarkson Says Lie to Your Doctor — Do Cancer Screens Save Lives?
When Jeremy Clarkson went public about surviving prostate cancer, he offered some blunt advice: if your doctor won't test you, lie to get the test. The clip spread quickly — and it raised a questio...
What Is a Normal Blood Pressure? Finding the Right Target for You
What is a normal blood pressure — and what should you actually be aiming for? The honest answer is that there is no single healthy blood pressure target that fits everyone. The right number depends...
Epicardial Fat: How to Reduce the Fat Around Your Heart
There's a type of fat that sits in direct contact with the heart. Because there's no barrier between it and the heart, it pumps inflammatory molecules — things like interleukin-6 and TNF-alpha — st...
Antioxidant Supplements: When High Doses Help and When They Harm
Earlier this month, one of the most rigorous trials ever run on a vitamin was stopped early — because the people getting the vitamin were dying faster than the people getting nothing [1]. It was vi...
Vitamin K2 and Coronary Calcium: Does It Protect Your Heart?
A year ago, the heart evidence for vitamin K2 looked intriguing but unproven — the field was waiting on a bigger, cleaner trial before anyone got excited. That trial has now landed, and it did exac...
Do Anti-Aging Supplements Actually Work? The Fisetin Evidence
There's a man in Wales who earns millions of dollars by reading other people's research. He sits down with papers that have already passed peer review, already been printed in the biggest journals ...