
Fall Asleep Faster, Sleep Deeper, Wake Refreshed
Sleep is a blend of sustained-release melatonin, fully chelated magnesium bisglycinate, and glycine to help you fall asleep faster, sleep through the night, and wake up refreshed. Each ingredient does a different job, and each is backed by human trials. Here’s how they work:
Version 2 (2026): melatonin moved from 0.3 mg immediate-release to 0.8 mg sustained-release (Melotime®), the magnesium is now fully chelated bisglycinate, and glycine is 2,400 mg. The full list of changes is in the FAQ below.
Low-Dose, Sustained-Release Melatonin (0.8 mg)
A Gentle Signal, Released Slowly
Melatonin is the body’s natural “sleep hormone.” Meta-analyses of clinical trials show that melatonin can help people fall asleep faster [1] and improve overall sleep quality [2].
Most supplements get the dose wrong. You will often see 3 mg or even 5 mg capsules on the shelf. These flood your receptors with far more hormone than your body ever makes in a night. Sleep bases the dose on human physiology instead.
The Science of the Low Dose
Each night, your body produces somewhere between 10 and 80 mcg of melatonin [15]. One study that tracked it in the blood found about 22 mcg a night in women and 36 mcg in men [3]. Another measured its breakdown product in overnight urine and found about 18 to 24 mcg a night in healthy adults [4]. That small amount is enough to start your natural sleep process. But only about 15% of oral melatonin reaches your bloodstream [5]. The rest is lost to poor absorption or broken down by the liver [5].
Sleep contains 0.8 mg (800 mcg) of melatonin. That 15% figure comes from a study of 2 mg and 4 mg tablets; applied to 0.8 mg, it gives an estimated 120 mcg reaching your bloodstream, spread across the evening and the night rather than arriving all at once. That is a few times what your body makes on its own, and a small fraction of what a 3 mg capsule delivers.
Why sustained release?
Ordinary melatonin peaks within about an hour and its blood level falls within a few hours. That helps you fall asleep, and it leaves little melatonin for later in the night. Sleep uses Melotime®, a sustained-release form. In a head-to-head study of 5 mg capsules in 16 people, funded by the ingredient’s manufacturer, with two authors employed by it, the sustained-release capsule reached half the peak level of the immediate-release capsule, and its level took about 5 hours to fall by half, against 1 hour [14]. Levels after hour 4 were higher with sustained release, but that difference was not statistically significant. That study did not test Sleep’s 0.8 mg dose. The dose is released gradually: a lower peak, and a lower level kept going later into the night.
Why 3 to 4 hours before bed?
Take Sleep 3 to 4 hours before you want to fall asleep. The label's 3 hours sits inside that range. In a small study, young adults who took a low dose of melatonin (0.3 mg or 1 mg) 2 to 4 hours before bed fell asleep sooner than with a placebo [7]. The slow release then keeps a lower level going later into the night.
Why not take more?
In an MIT study, researchers compared 0.1 mg, 0.3 mg, and 3.0 mg in adults over 50 with sleep difficulties [6]. The 0.3 mg dose restored sleep efficiency and raised melatonin to normal nighttime levels. The 3.0 mg dose also improved sleep, but it lowered body temperature and kept melatonin elevated well into the daylight hours.
A separate study in healthy young adults found that 0.3 mg of melatonin shortened the time to fall asleep without any "hangover effects" the next morning [7]. Richard Wurtman, who led the MIT research, has said that at about 10 times the effective dose, melatonin can stop working after a few days because the brain’s receptors stop responding [8]. Wurtman has a stake in this view: he and MIT patented low-dose melatonin, and a supplement company (not the maker of Sleep) licensed it [8].
Sleep sits between 0.3 mg and 3 mg: a low dose, released slowly, and about a quarter of the smallest common 3 mg capsule.
Magnesium Bisglycinate (126 mg elemental, fully chelated)
Magnesium Bisglycinate (Fully Chelated)
Magnesium is an essential mineral that supports relaxation and healthy sleep. Sleep includes 126 mg of elemental magnesium as fully chelated bisglycinate: every magnesium is bound to two glycine molecules. The glycine it carries counts toward the glycine dose below.
In an 8-week trial, 46 older adults with poor sleep took either 500 mg of magnesium a day (as magnesium oxide) or a placebo. The magnesium group slept longer, spent more of their time in bed asleep, and fell asleep faster [9]. A 2021 review pooled that trial with one other small trial, both using magnesium oxide at 500 to 729 mg a day: people fell asleep about 17 minutes sooner than with placebo, and the review rated the evidence low to very low quality [10]. Neither trial used magnesium bisglycinate or the 126 mg dose in Sleep.
Glycine (2,400 mg)
The Sleep-Supporting Amino Acid
Glycine is a naturally occurring amino acid that has been studied in several human trials for its impact on sleep. It has calming neuromodulator effects.
Three small trials found that taking 3 grams of glycine before bed can improve sleep quality, reduce time to fall asleep, and reduce fatigue the next day [11][12][13]. Sleep includes 2,400 mg of glycine per serving, counting the glycine carried by the magnesium chelate, to help you fall asleep more easily and wake up with more energy and a clearer head.
Clean, Natural, and Blue
- No artificial colors or dyes – We use natural blue spirulina for a calming bluish hue, reminiscent of the night sky.
- No titanium dioxide – A synthetic colorant often used in supplements, but not here.
- Plant-based – Made from plant-based materials with no genetically modified ingredients.
- No unnecessary fillers – Every ingredient has a purpose. No fluff.
- Non-habit-forming, low dose, made for nightly use
- Third-party tested – Certified by Labdoor, with independent analysis by Eurofins. Label accuracy, purity, and microbiology all passed. See the Labdoor report.
Assurance qualité
Nous nous sommes associés à un fabricant américain de compléments alimentaires, « Makers Nutrition », pour produire MicroVitamin. Leurs installations sont auditées GMP et enregistrées auprès de la FDA, vous pouvez donc être assuré que MicroVitamin est méticuleusement produit et minutieusement testé pour la qualité.
Voici les labels d'approbation pour lesquels Makers Nutrition est qualifié :
Why Most Sleep Supplements Get It Wrong
More isn't better when it comes to sleep ingredients. Most supplements use several times too much melatonin, release it all at once, and pick the cheapest form of magnesium. Sleep is formulated around what the evidence supports.
| Most Sleep Supplements | Sleep | |
|---|---|---|
| Melatonin dose | 3–10 mg, all at once | 0.8 mg, sustained release |
| Magnesium form | Oxide | Bisglycinate, fully chelated |
| Glycine | Not included | 2,400 mg |
| Unnecessary additives | Common | None |
Tap any question below
Foire aux questions
Le sommeil est-il végétalien/végétarien ?
Oui, les gélules Sleep by Dr Brad sont véganes. L'enveloppe de la gélule est d'origine végétale (sans gélatine), et aucun des ingrédients n'est dérivé d'animaux.
Pourquoi utiliser ce complément 2 heures avant de vouloir s'endormir ?
La mélatonine est un agent chronobiotique, ce qui signifie qu'elle aide à réguler le cycle veille-sommeil du corps.
Elle fonctionne mieux comme supplément lorsqu'elle est prise avant que la mélatonine naturelle du corps ne commence à augmenter le soir (généralement environ 2 heures avant de vouloir s'endormir).
Cela aide à avancer le cycle veille-sommeil, vous aidant ainsi à vous endormir plus rapidement.
Qu'est-ce que la spiruline ?
La spiruline est une algue bleu-vert naturelle (cyanobactérie). Elle contient également un pigment bleu vif appelé phycocyanine, dont l'extrait est utilisé comme colorant naturel dans les aliments et les compléments. Dans ce produit, la couleur bleue des gélules provient de la spiruline plutôt que de colorants artificiels.
Pourquoi y a-t-il un avertissement de la Proposition 65 ?
Étant donné qu'il s'agit du premier lot de fabrication, nous avons été tenus d'afficher l'avertissement de la Proposition 65 de la Californie.
Maintenant que nous avons terminé notre premier lot et démontré avec notre certificat d'analyse qu'il s'agit d'un produit de haute qualité, pour les futurs lots, nous pourrons supprimer l'avertissement Prop65.
Pourquoi la dose de mélatonine n'est-elle que de 300 µg (beaucoup plus faible que de nombreux autres somnifères) ?
La plupart des suppléments de mélatonine en vente libre contiennent 3 000 à 10 000 mcg (3 à 10 mg), ce qui est bien supérieur à la production naturelle nocturne de mélatonine par l'organisme (environ 20 à 35 mcg) [3, 4].
Des doses élevées peuvent rester dans la circulation sanguine jusqu'au lendemain matin, provoquant potentiellement des étourdissements ou une désensibilisation hormonale au fil du temps [6]. En revanche, 300 mcg (0,3 mg) est une dose physiologique dont il a été démontré dans des essais cliniques qu'elle améliorait l'efficacité du sommeil tout aussi efficacement que des doses plus élevées, mais sans les effets secondaires [6].
Cette approche soutient le rythme naturel de votre corps sans le surcharger.
What changed in Sleep version 2?
Version 2 (batch dated February 2026, on sale from August 2026) makes three changes to the formula. Price, serving size (4 capsules) and bottle size (30 servings) are unchanged.
1. Melatonin: 0.3 mg immediate-release became 0.8 mg sustained-release (Melotime®). The version 1 dose helped people fall asleep, but immediate-release melatonin peaks within about an hour and its blood level falls within a few hours. Version 2 releases the melatonin gradually, so a lower level is kept going later into the night. The dose is higher because only about 15% of an oral dose reached the bloodstream in a study of 2 mg and 4 mg tablets [5], and what is absorbed is now spread across roughly 8 hours instead of arriving at once. Using the same 15%, an estimated 120 mcg of Sleep’s melatonin reaches the bloodstream (Sleep itself has not been tested), against about 450 mcg from a 3 mg capsule.
2. Magnesium is now fully chelated bisglycinate. The magnesium glycinate in version 1 was not fully chelated. In version 2 every magnesium is bound to two glycine molecules. Elemental magnesium stays at 126 mg.
3. Glycine: 2,500 mg became 2,400 mg. The label now counts the glycine carried by the magnesium chelate, and 2,400 mg is the most that fits in a 4-capsule serving. The glycine trials used 3 g [11, 12, 13], so version 2 stays close to that dose without moving to 5 capsules.
Because the melatonin now releases slowly, the label's timing moved from 2 hours to 3 hours. Take it 3 to 4 hours before you want to fall asleep. Version 2 is also third-party tested: certified by Labdoor with independent analysis by Eurofins. See the Labdoor report.
Peut-on prendre ce supplément tous les soirs à long terme sans danger ?
Oui, ce complément est conçu pour un usage régulier et contient des ingrédients considérés comme sûrs pour une utilisation à long terme chez les adultes en bonne santé.
La mélatonine a été étudiée dans des essais cliniques sans preuve de sevrage ou de tolérance à faibles doses [1, 2].
Le magnésium et la glycine sont des nutriments essentiels ou des acides aminés avec d'excellents profils de sécurité lorsqu'ils sont utilisés dans les fourchettes de supplémentation typiques [9, 10] et [11, 12, 13].
Comme toujours, consultez votre professionnel de la santé si vous avez des problèmes de santé sous-jacents ou si vous prenez des médicaments qui affectent le sommeil ou la neurotransmission.
Vais-je me sentir groggy le lendemain matin après l'avoir pris ?
Peu probable. Contrairement aux suppléments de mélatonine à forte dose qui peuvent laisser une somnolence résiduelle, la dose de 300 mcg de cette formule est suffisamment faible pour disparaître au matin, ce qui vous aide à éviter l'effet de « gueule de bois à la mélatonine » [6, 7].
En fait, la recherche montre qu'une faible dose de mélatonine combinée à de la glycine peut vous aider à vous sentir plus frais et alerte le lendemain, et non groggy [13].
Ce supplément est formulé pour favoriser un sommeil réparateur tout en permettant un matin clair et énergique.
Un mot du Dr Brad Stanfield, médecin de premier recours
Mon objectif principal est de soutenir le bien-être de mon public. Je ne saurais trop insister sur le fait qu'une alimentation équilibrée passe avant tout, et je vous conseille vivement de consulter votre professionnel de la santé avant de commencer tout supplément.
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References
- Ferracioli-Oda, E., Qawasmi, A., & Bloch, M. H. (2013). Meta-analysis: Melatonin for the treatment of primary sleep disorders. PLoS One, 8(5), e63773. https://doi.org/10.1371/journal.pone.0063773
- Gholami, F., et al. (2022). Effect of melatonin supplementation on sleep quality: A systematic review and meta-analysis. Journal of Neurology, 269(1), 205–216. https://doi.org/10.1007/s00415-020-10381-w
- Fourtillan, J. B., et al. (2001). Melatonin secretion occurs at a constant rate in both young and older men and women. American Journal of Physiology-Endocrinology and Metabolism, 280(1), E11–E22. https://doi.org/10.1152/ajpendo.2001.280.1.E11
- Leger, D., Laudon, M., & Zisapel, N. (2004). Nocturnal 6-sulfatoxymelatonin excretion in insomnia and its relation to the response to melatonin replacement therapy. The American Journal of Medicine, 116(2), 91–95. https://doi.org/10.1016/j.amjmed.2003.07.017
- DeMuro, R. L., et al. (2000). The absolute bioavailability of oral melatonin. Journal of Clinical Pharmacology, 40(7), 781–784. https://doi.org/10.1177/00912700022009422
- Zhdanova, I. V., et al. (2001). Melatonin treatment for age-related insomnia. Journal of Clinical Endocrinology & Metabolism, 86(10), 4727–4730. https://doi.org/10.1210/jcem.86.10.7901
- Zhdanova, I. V., et al. (1996). Effects of low oral doses of melatonin, given 2-4 hours before habitual bedtime, on sleep in normal young humans. Sleep, 19(5), 423-431. https://doi.org/10.1093/sleep/19.5.423
- Thomson, E. A. (2005, March 1). Rest easy: MIT study confirms melatonin's value as sleep aid. MIT News. https://news.mit.edu/2005/melatonin
- Abbasi, B., et al. (2012). The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. Journal of Research in Medical Sciences, 17(12), 1161–1169. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703169/
- Mah, J., & Pitre, T. (2021). Oral magnesium supplementation for insomnia in older adults: A systematic review & meta-analysis. BMC Complement Med Ther, 21, 125. https://doi.org/10.1186/s12906-021-03297-z
- Inagawa, K., et al. (2006). Subjective effects of glycine ingestion before bedtime on sleep quality. Sleep and Biological Rhythms, 4(1), 75–77. https://doi.org/10.1111/j.1479-8425.2006.00193.x
- Bannai, M., et al. (2012). The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. Frontiers in Neurology, 3, 61. https://doi.org/10.3389/fneur.2012.00061
- Yamadera, W., et al. (2007). Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes. Sleep and Biological Rhythms, 5(2), 126–131. https://doi.org/10.1111/j.1479-8425.2007.00262.x
- Thanawala, S., Abiraamasundari, R., & Shah, R. (2024). Comparative pharmacokinetics of sustained-release versus immediate-release melatonin capsules in fasting healthy adults: A randomized, open-label, cross-over study. Pharmaceutics, 16(10), 1248. https://doi.org/10.3390/pharmaceutics16101248
- Kor, Y., et al. (2014). Preliminary study: Evaluation of melatonin secretion in children and adolescents with type 1 diabetes mellitus. Indian Journal of Endocrinology and Metabolism, 18(4), 565–568. https://doi.org/10.4103/2230-8210.137521