Does Ezetimibe Work? What the Evidence Shows
Category: Research
NMN and NR Supplements: What the Human Evidence Actually Shows
Over the last decade, NMN and NAD+ supplements were hyped as groundbreaking tools in the fight against aging. Boost your NAD+ levels, the story went, and you might slow aging, boost energy, and eve...
Shingles Vaccine and Dementia Risk: What the Research Now Shows
Something remarkable has emerged from a completely unexpected corner of medicine. Medicine is full of examples where there's been failure after failure to treat a specific health condition, only fo...
Coffee and Heart Health: What the Research Actually Shows
There was absolute panic in 1981. Imagine sitting at the table, enjoying a morning cup of coffee, with the day's paper spread out in front of you. Your eyes fall on a headline in bold, black letter...
Retatrutide Phase 3 Trial: 28.7% Weight Loss Compared to Tirzepatide
A phase 3 clinical trial has demonstrated 28.7% weight loss over 68 weeks with a new drug called retatrutide. The trial also showed substantial relief from knee osteoarthritis pain — an unexpected ...
PCSK9 Inhibitors: How Gene-Guided Therapy Is Transforming Heart Disease Prevention
A revolutionary approach to cholesterol-lowering has changed the landscape of cardiovascular medicine. For decades, LDL cholesterol has been recognised as a central driver of heart disease. But rec...
Omega-3 Fish Oil and Heart Health: What the Evidence Shows
Table of Contents Early Promise, Followed by Disappointments A New Breakthrough in High-Risk Patients What This Means for the Rest of Us References Omega-3 research has had its share of failures...
What the TARGET-D Trial Reveals About Vitamin D and Heart Health
A new vitamin D trial has raised important questions about the advice clinicians give — and the approach many have taken to vitamin D testing and supplementation. Because it takes a novel approach,...
Blood Pressure Targets: What the Evidence Actually Says
Is something significant happening right under our noses? There is a change that has quietly crept up over the past few decades — so gradual that most people have barely noticed. Since the 1970s, d...
Normal BMI, Hidden Heart Risk: What Waist Circumference Reveals
Many people feel reassured when their BMI falls in the normal range. The scale shows a healthy number, the ratio of weight to height looks right — and at a time when obesity rates are high, a norma...
Melatonin and Heart Failure: What the 89% Headline Gets Wrong
People who use melatonin supplements have an 89% higher risk of developing heart failure, according to a new study of over 130,000 adults [1]. And there were two other equally grim findings covered...
IV Therapy Clinics: The Risks, Costs, and Lack of Evidence
It's a nearly $3 billion market and growing fast. IV therapy clinics—where you can get cocktails of vitamins and other nutrients dripped directly into your veins—are supposed to do everything from ...
The Testosterone Decline Myth: What the Science Actually Shows
For years, researchers have observed a troubling trend: testosterone levels in men seem to be declining across generations. This hormone, crucial for male health, has been linked to energy, mood, m...
Vigorous Exercise Benefits: How Intensity Multiplies Health Outcomes
A landmark study has overturned one of the most fundamental assumptions in exercise science — and the implications reshape how anyone should structure their physical activity for maximum health ben...
Fatty Liver Disease: GLP-1 Medications, Diet, and Lifestyle Treatment Guide
GLP-1 medications have emerged as a significant advance in treating fatty liver disease — the FDA approved semaglutide (Wegovy) for this indication in 2024. But which GLP-1 is most effective? How s...
Longevity Clinics Are Over-Testing You — What the Evidence Shows
There's an engineering concept that applies directly to medicine: "the best part is no part. The best process is no process." In clinical practice, sometimes the best test is no test, and the best ...
Resistance Training and Aging: How Exercise Preserves Muscle Function
A world-renowned researcher, Dr. Brad Schoenfeld, recently highlighted a study he described as "the closest thing we have to the fountain of youth" [1]. This article explores that study and Dr. Sc...
Colchicine and Heart Disease: How Inflammation Drives Cardiovascular Risk
A new study published in the European Heart Journal found that a cheap anti-inflammatory drug cuts heart disease risk by 12%. The finding highlights something many people overlook: inflammation is ...
GLP-1 and SGLT2 Inhibitors: What the Evidence Shows on Dementia Risk
GLP-1 agonists like Ozempic were a turning point in the management of type 2 diabetes. Combined with SGLT2 inhibitors—a second class of diabetes medication—these treatments transformed outcomes for...
Taurine Supplements and Aging: What Two New Studies Reveal
Two years ago, a breakthrough study yielded exciting evidence that taurine could help combat aging. But a study published since then casts serious doubt on those earlier results. And this is actual...
Bone Loss After 40: How to Protect Bone Density with Exercise and Nutrition
One in three people who break their hip will be dead within 1 year. After 10 years, only 8.5% will be alive, compared to 39.8% in the general population [1]. Those numbers reflect a broader pattern...
Lowering Blood Pressure: Why the 120 Target Cuts Heart Risk by 21%
Table of Contents The new study The revision At-home BP measurement Reducing high BP Reference list The new study A new study reinforces why the medical approach to lowering heart attack risk i...
Vitamin D Dosing for Immune Health: What the Research Actually Shows
There's been so much hype around vitamin D—and, unfortunately, most studies have been disappointing when it comes to real-world benefits. But a brand-new study points to a place where vitamin D see...
MyPlate vs the Healthy Eating Plate: What the Evidence Says
The Food Pyramid is probably the most widely recognised guide to healthy nutrition, yet nutrition scientists raised concerns from the start. This article explains why it was eventually abandoned, w...
Collagen Peptides for Skin: What the Evidence Shows
Collagen is simple, safe, and well-studied, and the evidence increasingly supports its ability to improve markers of skin health. A 2025 randomized controlled trial adds to this picture — and also ...