LDL, ApoB and Heart Attack Risk: What the Evidence Shows
Category: Preventative Care
LDL, ApoB and Heart Attack Risk: What the Evidence Shows
Age-adjusted deaths from heart disease in the United States fell 72.6% between 1950 and 2019, from 588.8 to 161.5 per 100,000 [1]. That decline did not come from one breakthrough. It came from iden...
Vitamin K2 and Artery Calcification: What Two 2026 Trials Found
Two randomized trials published in 2026 found that vitamin K2 slowed the build-up of calcium in coronary arteries. A Dutch trial in people with moderate calcium scores reported a 22-unit smaller ri...
Every Cancer Vaccine Failed, Until Now
On August 19, 2026, Merck and Moderna announced that the first Phase 3 trial of an individualized cancer vaccine had met its endpoints in melanoma — and Moderna's share price rose 177% in one tradi...
Do Multivitamins Actually Work? What The Trials Show
"Expensive urine" is the most durable criticism ever levelled at multivitamins. It dates from a 2007 television segment, it is repeated constantly, and for years it was a fair reading of the scienc...
How To Increase Bone Density: What Actually Works
Bone density is one of the few areas of health where the popular advice and the trial evidence point in genuinely different directions. Most people reach for a calcium supplement. The research keep...
Does Lowering IL-6 Inflammation Reduce Heart Disease? What The Trials Show
Chronic inflammation has been named as a driver of heart disease for the better part of three decades. That claim now has its cleanest test — and the answer is not the one the field expected. In J...
Does Ezetimibe Work? What the Evidence Shows
In August 1990, a chemist named Duane Burnett walked into John Clader's office in New Jersey to discuss the results of their failed experiment. Together, they had spent months building molecules to...
What Is a Normal Blood Pressure? Finding the Right Target for You
What is a normal blood pressure — and what should you actually be aiming for? The honest answer is that there is no single healthy blood pressure target that fits everyone. The right number depends...
Epicardial Fat: How to Reduce the Fat Around Your Heart
There's a type of fat that sits in direct contact with the heart. Because there's no barrier between it and the heart, it pumps inflammatory molecules — things like interleukin-6 and TNF-alpha — st...
Vitamin K2 and Coronary Calcium: Does It Protect Your Heart?
A year ago, the heart evidence for vitamin K2 looked intriguing but unproven — the field was waiting on a bigger, cleaner trial before anyone got excited. That trial has now landed, and it did exac...
Bemotrizinol: The New Anti-Aging Sunscreen Filter the FDA Just Approved
Walk into a pharmacy in Europe, Japan, or Australia and you’ll find a sunscreen ingredient that protects skin from the signs of aging better than almost anything sold in the United States — without...
PCSK9 Gene Editing and LDL Cholesterol: How VERVE-102 Works
In April 2024, the trial that was supposed to end heart disease at the source nearly ended in disaster. One of the initial patients to receive the world's first gene-editing infusion designed to p...
Low-Dose Tirzepatide (Zepbound): Evidence Beyond Weight Loss
Tirzepatide — the active ingredient in Mounjaro and Zepbound — was designed as a blood-sugar drug. But across a sequence of large randomised trials, it and its GLP-1 cousins have kept producing ben...
Shingles Vaccine and Cardiovascular Health: What the Research Shows
In 2023, a Stanford researcher named Pascal Geldsetzer was examining the way Wales had rolled out the shingles vaccine a decade earlier — and noticed something peculiar. To ration the limited supp...
Early-Onset Colon Cancer: Three Research Teams, Three Suspects
Colon cancer rates in people under 50 have roughly doubled in twenty years. Nobody knows why. The incidence in the sigmoid colon nearly doubled from 1998 to 2022 in people aged 20–49, and 22% of al...
Aspirin and Cancer Prevention: What the Latest Evidence Shows
In 2010, an Oxford neurologist named Peter Rothwell published a paper in The Lancet that rewrote medical guidelines around the world. After analyzing eight randomized trials and twenty-five thousan...
Statins and Cholesterol: Separating Side-Effect Myths from the Evidence
Fifty-five years ago, a Japanese biochemist by the name of Akira Endo isolated a compound from a mold growing on rice in a Kyoto grain shop. It would go on to prevent more heart attacks than almost...
Heart Attack Risk Factors: What Research on 9 Million People Reveals
On July 20, 1984, Jim Fixx — the man whose bestselling book on running had inspired millions of Americans to get in shape — dropped dead of a massive heart attack during his daily run on a quiet Ve...
The LDL Cholesterol Target the Evidence Actually Supports
In 2006, researchers in Dallas found a woman who broke everything science thought it knew about cholesterol. She was 32 years old. A healthy aerobics instructor. Normal liver, normal kidneys, no h...
Full-Body MRI Scans: What the Evidence Says Before You Book One
Table of Contents The Promise The Controversy What the Evidence Shows References A booming industry is selling full-body MRI scans directly to the public — no doctor referral required. Celebriti...
High-Volume Exercise and Arterial Plaque: What the Evidence Really Shows
A study just published reveals a startling relationship that's the opposite of what most assume. It found that the most heavily trained athletes were almost six times more likely to have plaque in ...
Skin Aging: Evidence-Based Guide to Diet, Exercise, Sleep, Sunscreen, and Retinoids
Here are the most evidence-backed, affordable strategies to reduce the signs of skin aging — based on the latest human clinical research. The good news: most of them cost nothing at all. Table of ...
Coffee and Dementia Risk: What a 131,821-Person Study Found
Right now, more than 7 million Americans are living with Alzheimer's disease. By 2060, that number is projected to nearly double to 13.8 million people. Between 2000 and 2022, deaths from Alzheimer...
Nitric Oxide Supplements: What the Research Actually Shows
Nitric oxide supplement research is more promising than many people expect—but the gap between clinical evidence and what supplement companies actually deliver is striking. This article breaks down...