LDL, ApoB and Heart Attack Risk: What the Evidence Shows
Category: Research
LDL, ApoB and Heart Attack Risk: What the Evidence Shows
Age-adjusted deaths from heart disease in the United States fell 72.6% between 1950 and 2019, from 588.8 to 161.5 per 100,000 [1]. That decline did not come from one breakthrough. It came from iden...
Daraxonrasib, RAS Inhibitors and Personalized Cancer Vaccines: What Changed in 2026
On August 26, 2026, the US Food and Drug Administration approved daraxonrasib for adults with metastatic pancreatic cancer that had already been treated once [1]. On its own, one approval is a head...
Vitamin K2 and Artery Calcification: What Two 2026 Trials Found
Two randomized trials published in 2026 found that vitamin K2 slowed the build-up of calcium in coronary arteries. A Dutch trial in people with moderate calcium scores reported a 22-unit smaller ri...
Why Iodine Deficiency Is Coming Back (and How to Get Enough)
For most of the twentieth century, Americans got more iodine than they needed without ever thinking about it. That is no longer true. National survey data show median iodine levels in US adults fel...
Every Cancer Vaccine Failed, Until Now
On August 19, 2026, Merck and Moderna announced that the first Phase 3 trial of an individualized cancer vaccine had met its endpoints in melanoma — and Moderna's share price rose 177% in one tradi...
Do GLP-1 Drugs Cause Blindness? What The Evidence Shows
A claim made on a major podcast in August 2026 — that sudden blindness has doubled because of GLP-1 medicines — travelled a long way in a short time [1]. It is worth separating what the underlying ...
Do Multivitamins Actually Work? What The Trials Show
"Expensive urine" is the most durable criticism ever levelled at multivitamins. It dates from a 2007 television segment, it is repeated constantly, and for years it was a fair reading of the scienc...
How To Increase Bone Density: What Actually Works
Bone density is one of the few areas of health where the popular advice and the trial evidence point in genuinely different directions. Most people reach for a calcium supplement. The research keep...
Does Lowering IL-6 Inflammation Reduce Heart Disease? What The Trials Show
Chronic inflammation has been named as a driver of heart disease for the better part of three decades. That claim now has its cleanest test — and the answer is not the one the field expected. In J...
Does Ezetimibe Work? What the Evidence Shows
In August 1990, a chemist named Duane Burnett walked into John Clader's office in New Jersey to discuss the results of their failed experiment. Together, they had spent months building molecules to...
BPC-157: Does It Work, and Did It Just Get FDA Approval?
BPC-157 is one of the most talked-about peptides on the internet. Athletes inject it for tendon and joint injuries, podcast guests credit it with fixing pain that nothing else could touch, and in J...
What Is a Normal Blood Pressure? Finding the Right Target for You
What is a normal blood pressure — and what should you actually be aiming for? The honest answer is that there is no single healthy blood pressure target that fits everyone. The right number depends...
Antioxidant Supplements: When High Doses Help and When They Harm
Earlier this month, one of the most rigorous trials ever run on a vitamin was stopped early — because the people getting the vitamin were dying faster than the people getting nothing [1]. It was vi...
Vitamin K2 and Coronary Calcium: Does It Protect Your Heart?
A year ago, the heart evidence for vitamin K2 looked intriguing but unproven — the field was waiting on a bigger, cleaner trial before anyone got excited. That trial has now landed, and it did exac...
Do Anti-Aging Supplements Actually Work? The Fisetin Evidence
There's a man in Wales who earns millions of dollars by reading other people's research. He sits down with papers that have already passed peer review, already been printed in the biggest journals ...
Bemotrizinol: The New Anti-Aging Sunscreen Filter the FDA Just Approved
Walk into a pharmacy in Europe, Japan, or Australia and you’ll find a sunscreen ingredient that protects skin from the signs of aging better than almost anything sold in the United States — without...
Muscle Loss on GLP-1 Drugs: What the Evidence Actually Shows
In 2004, a baby was born in Germany who was, by any normal measure, impossible. He was a few days old, and he already had visible muscles — his thighs and upper arms looked like a tiny bodybuilder....
The Undruggable Gene: How Daraxonrasib Doubled Survival in Pancreatic Cancer
A room full of cancer doctors rose to their feet at the 2026 American Society of Clinical Oncology (ASCO) conference, applauding the full results of a new cancer trial [1][2] — one with the potenti...
PCSK9 Gene Editing and LDL Cholesterol: How VERVE-102 Works
In April 2024, the trial that was supposed to end heart disease at the source nearly ended in disaster. One of the initial patients to receive the world's first gene-editing infusion designed to p...
Microplastics Research: Why the Headlines Are Wrong (and What Actually Matters)
Madeline Clough, a grad student at the University of Michigan, stumbled upon something that would turn out to be quite embarrassing for the microplastics research field. The popular claim is that ...
Low-Dose Tirzepatide (Zepbound): Evidence Beyond Weight Loss
Tirzepatide — the active ingredient in Mounjaro and Zepbound — was designed as a blood-sugar drug. But across a sequence of large randomised trials, it and its GLP-1 cousins have kept producing ben...
Omega-3 and Brain Health: What a 2026 Alzheimer's Study Got Wrong
Table of Contents The Study Landed What The Study Didn't Measure — The Bottle What The Study Didn't Measure — The Co-Factor What The Evidence Suggests References In 2024, a video titled Your Bra...
Shingles Vaccine and Cardiovascular Health: What the Research Shows
In 2023, a Stanford researcher named Pascal Geldsetzer was examining the way Wales had rolled out the shingles vaccine a decade earlier — and noticed something peculiar. To ration the limited supp...
Seed Oils and Health: What the Evidence Actually Shows
The internet is awash with videos and articles warning about the dangers of seed oils — that they're toxic, inflammatory, and terrible for human health. This article examines where these concerns c...