LDL, ApoB and Heart Attack Risk: What the Evidence Shows
Melatonin and Heart Failure: What the 89% Headline Gets Wrong
People who use melatonin supplements have an 89% higher risk of developing heart failure, according to a new study of over 130,000 adults [1]. And there were two other equally grim findings covered...
IV Therapy Clinics: The Risks, Costs, and Lack of Evidence
It's a nearly $3 billion market and growing fast. IV therapy clinics—where you can get cocktails of vitamins and other nutrients dripped directly into your veins—are supposed to do everything from ...
Vitamin A: Forms, Benefits, Dosing, and Safety
Vitamin A is the name of a group of fat-soluble retinoids — primarily retinol and retinyl esters — that are essential for vision, immune function, cellular communication, growth, development, and r...
The Testosterone Decline Myth: What the Science Actually Shows
For years, researchers have observed a troubling trend: testosterone levels in men seem to be declining across generations. This hormone, crucial for male health, has been linked to energy, mood, m...
Valerian Root: Benefits, Forms, Dosing, and Side Effects
Valerian (Valeriana officinalis) is a perennial herb native to Europe and temperate regions of Asia, whose roots and rhizomes have been used as a sedative and anxiolytic for over 2,000 years. Hipp...
Cholesterol and Dementia Risk: What a 1-Million-Person Study Reveals
A study of over 1 million people has found impressive dementia risk reductions linked to cholesterol management — offering some of the strongest evidence yet on how long-term LDL lowering affects b...
Vigorous Exercise Benefits: How Intensity Multiplies Health Outcomes
A landmark study has overturned one of the most fundamental assumptions in exercise science — and the implications reshape how anyone should structure their physical activity for maximum health ben...
Taurine Supplement Guide: Evidence, Dosing, and Forms
Taurine (2-aminoethanesulfonic acid) is a water-soluble amino sulfonic acid found abundantly throughout the human body, with particularly high concentrations in the heart, brain, retina, and skelet...
Lead in Protein Powders: What the Research Actually Shows
A new analysis from Consumer Reports has made headlines with a disturbing claim: protein powders and shakes contain high levels of lead. Given how popular protein powders have become, this claim is...
Fatty Liver Disease: GLP-1 Medications, Diet, and Lifestyle Treatment Guide
GLP-1 medications have emerged as a significant advance in treating fatty liver disease — the FDA approved semaglutide (Wegovy) for this indication in 2024. But which GLP-1 is most effective? How s...
St. John's Wort: Evidence-Based Guide to Benefits, Dosing, and Safety
St. John's wort (Hypericum perforatum) is a flowering plant used medicinally for centuries across Greek, Islamic, and Chinese traditional medicine systems [1][2]. The aerial parts contain at least ...
Artificial Sweeteners and the Gut Microbiome: What the RCT Evidence Shows
Table of Contents The puzzle The study Gut microbiome findings Safety Recommendations Final Verdict References One of the largest artificial sweetener studies has just been released, helping to ...
Polypharmacy and Deprescribing: When Medications Do More Harm Than Good
Over 40% of adults over 75 are prescribed 5 or more medications [1]. While those medications may have been appropriate at prescription, the risk–benefit balance shifts as the body ages—and drugs th...
Shilajit: Evidence-Based Guide to Benefits, Forms, Dosing, and Safety
Table of Contents Overview Chemical Composition Geological Formation and Traditional Grading Forms and Bioavailability Evidence for Benefits Recommended Dosing Safety and Side Effects Drug Interac...
GLP-1 Microdosing for Healthy Adults: What the Evidence Actually Shows
Tech entrepreneur Bryan Johnson stirred up considerable interest when he began a microdosing experiment in late 2024 [1]. His experiment had some unexpected results — as we'll see in a moment. And...
Sexual Enhancement Supplements: Evidence-Based Guide to Ingredients, Dosing, and Safety
Sexual enhancement supplements are among the most heavily marketed dietary supplements, typically containing herbal extracts such as yohimbe bark, epimedium (horny goat weed), maca root, and ginsen...
Vitamin D and Telomeres: What the VITAL Study Actually Shows
Recent headlines claimed a new study shows vitamin D can slow aging. But what does the research actually show — and what does it mean for vitamin D dosing and testing decisions? Table of Contents ...
Ashwagandha for Exercise Performance: What the Research Actually Shows
A new clinical study has found no benefit of ashwagandha supplementation on aerobic capacity, muscle oxygenation, or blood parameters in healthy men. If currently taking ashwagandha for athletic pe...
Spirulina Supplements: What the 2025 Meta-Analyses Actually Show
A 2025 meta-analysis suggests spirulina—a blue-green algae extract—can improve body weight, cholesterol, and blood pressure in overweight and obese individuals. The evidence is worth examining clos...
Selenium: Benefits, Forms, Dosing, and Safety
Selenium is a trace mineral essential for the biosynthesis of 25 distinct selenoproteins in the human body [1][2]. These selenoproteins incorporate selenium in the form of selenocysteine — the 21st...
Supplements With the Strongest Scientific Evidence
Table of Contents Psyllium Husk Multivitamin & Mineral Omega-3 Creatine TMG (Trimethylglycine / Betaine) Bonus: Melatonin Final Thoughts References Psyllium Husk Research has long recognised...
SAMe Supplement Guide: Benefits, Dosing, Forms, and Safety
Table of Contents Overview Forms and Bioavailability Evidence for Benefits Recommended Dosing Safety and Side Effects Drug Interactions Dietary Sources References Overview SAMe (S-adenosyl-L-met...
Magnesium Bisglycinate and Sleep: What a 155-Person Trial Found
Sleep is one of the most powerful tools available for health, yet many people struggle to get enough quality rest. While melatonin often gets the spotlight, a clinical trial published in 2025 teste...
Protein Intake Guide: How Much Do You Really Need?
These days, we're hearing constantly about the need for more protein. It's a trend driven by some of the biggest health influencers. And there's something to their arguments, as we'll see. But this...
Saffron Supplements: Evidence-Based Guide to Benefits, Forms, Dosing, and Side Effects
Saffron is derived from the dried stigmas of the crocus flower (Crocus sativus), a sterile, fall-blooming perennial in the Iridaceae family [1][2]. The plant produces vibrant purple flowers from wh...